Safety of maximal cardiopulmonary exercise testing in individuals with sickle cell disease: a systematic review.

ABSTRACT:

Objective

We evaluated the safety of maximal cardiopulmonary exercise testing (CPET) in individuals with sickle cell disease (SCD). Maximal CPET using gas exchange analysis is the gold standard for measuring cardiopulmonary fitness in the laboratory, yet its safety in the SCD population is unclear.

Design

Systematic review.

Data sources

Systematic search of Medline (PubMed), EMBASE, Cochrane, ClinicalTrials.gov and professional society websites for all published studies and abstracts through December 2020.

Eligibility criteria for selecting studies

Two reviewers independently extracted data of interest from studies that assessed safety outcomes of maximal CPET in children and adults with SCD. A modified version of the Newcastle-Ottawa Scale was used to assess f

SUBMITTER: Smith KN 

PROVIDER: S-EPMC8770664 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature