Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.

ABSTRACT:

Background

Hypertension and proteinuria are common bevacizumab-induced toxicities. No validated biomarkers are available for identifying patients at risk of these toxicities.

Methods

A genome-wide association study (GWAS) meta-analysis was performed in 1039 bevacizumab-treated patients of European ancestry in four clinical trials (CALGB 40502, 40503, 80303, 90401). Grade ≥2 hypertension and proteinuria were recorded (CTCAE v.3.0). Single-nucleotide polymorphism (SNP)-toxicity associations were determined using a cause-specific Cox model adjusting for age and sex.

Results

The most significant SNP associated with hypertension with concordant effect in three out of the four studies (p-value <0.05 for each study) was rs6770663 (A > G) in KCNAB1, with the G allele increasi

SUBMITTER: Quintanilha JCF 

PROVIDER: S-EPMC8770703 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature