The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma.

ABSTRACT:

Background

MAP2K1/2 genes are mutated in approximately 8% of melanoma patients; however, the impact of MAP2K1/2 gene alterations on the efficiency of immunotherapy has not been clarified. This study focused on the correlation between MAP2K1/2 gene mutations and the treatment response.

Methods

Six metastatic melanoma clinical cohorts treated with immune checkpoint inhibitors [anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) or anti-programmed cell death-1 (PD-1)] were recruited in this study. RNA expression profiling results from each of these six cohorts and the Cancer Genome Atlas (TCGA) melanoma cohort were analysed to explore the mechanism related to immune activation.

Results

Compared to patients with wild-type MAP2K1/2, those with MAP

SUBMITTER: Ye T 

PROVIDER: S-EPMC8770828 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature