C-Reactive Protein Is an Indicator of the Immunosuppressive Microenvironment Fostered by Myeloid Cells in Hepatocellular Carcinoma.

ABSTRACT:

Background

C-reactive protein (CRP) is a widely used marker of systemic inflammation and predicts poor clinical outcomes in patients with hepatocellular carcinoma (HCC); however, its significance in the local immune response at the tumor site is not clear.

Methods

Serum CRP levels of 329 HCC patients were detected before resection. Paired paraffin-embedded tumor samples were used to quantify immune cell populations, such as CD11b⁺ myeloid cells, CD68⁺ macrophages (Mφs), CD15⁺ neutrophils, CD8⁺ T cells, and CD206⁺, CD204⁺, CD163⁺ and CD169⁺ Mφs, by immunohistochemistry. Enrichment scores for 34 types of immune cells based on transcriptome data from 24 HCC samples were calculated by xCell.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8770831 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature