Gut Microbiota in Heart Failure Patients With Preserved Ejection Fraction (GUMPTION Study).

ABSTRACT: Introduction: Heart failure with preserved ejection fraction (HFpEF) is associated with disrupted intestinal epithelial function, resulting from intestinal congestion. Intestinal congestion changes the morphology and permeability of the intestinal wall, and it becomes easy for the gut microbiota to change and transfer. Intervention on gut microbiota may become a new target for HFpEF treatment. However, the characteristics of gut microbiota in patients with HFpEF remain unknown. This preliminary report aims to detect the structure of gut microbiota in HFpEF patients so as to explore their characteristic changes, thereby providing a theoretical basis for future research. Methods: This research recruited 30 patients diagnosed with HFpEF and 30 healthy individuals. Stool specimen

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8770938 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature