Expression of PD-L1 and CD4+ tumor-infiltrating lymphocytes predict survival in head and neck squamous cell carcinoma.

ABSTRACT: The clinical efficacy of immune checkpoint blockade has been recently demonstrated in a variety of cancer types. The aim of the present study was to characterize the expression profile of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1) in head and neck squamous carcinoma (HNSCC). A total of 63 patients with HNSCC were enrolled in the present study. CD3⁺ and CD4⁺ TILs and the expression of PD-L1 were detected by immunohistochemistry. PD-L1 mRNA levels were evaluated by reverse transcription-quantitative PCR analysis. The association of TILs and PD-L1 with patient clinicopathological characteristics was also assessed. CD3⁺ and CD4⁺ TILs were detected in 100% of the samples. CD3⁺ was the predominant subset of T

SUBMITTER: Fu ZM 

PROVIDER: S-EPMC8771311 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature