A prospective study of risk-based colposcopy demonstrates improved detection of cervical precancers.

ABSTRACT:

Background

Sensitivity for detection of precancers at colposcopy and reassurance provided by a negative colposcopy are in need of systematic study and improvement.

Objective

We sought to evaluate whether selecting the appropriate women for multiple targeted cervical biopsies based on screening cytology, human papillomavirus testing, and colposcopic impression could improve accuracy and efficiency of cervical precancer detection.

Study design

In all, 690 women aged 18-67 years referred to colposcopy subsequent to abnormal cervical cancer screening results were included in the study (ClinicalTrials.gov: NCT00339989). Up to 4 cervical biopsies were taken during colposcopy to evaluate the incremental benefit of multiple biopsies. Cervical cytology, human papillomavirus ge

SUBMITTER: Wentzensen N 

PROVIDER: S-EPMC8771458 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature