Identification of GINS2 prognostic potential and involvement in immune cell infiltration in hepatocellular carcinoma.

ABSTRACT: Background: GINS2 has been reported to have prognostic value in several solid tumors other than hepatocellular carcinoma (HCC), and its influence on tumor immunity has not been investigated thus far. Methods: The transcriptome profiles were retrieved from two public databases, GEO and TCGA. The median GINS2 expression was considered as cutoff to define GINS2 ^high and GINS2 ^low groups and to obtain differentially expressed genes. These genes were then subjected to KEGG pathway and gene ontology (GO) analysis and to gene set enrichment analysis (GSEA). Survival analyses according to GINS2 level were performed utilizing Kaplan-Meier plotter. TIMER database was adopted to investigate associations between GINS2 level

SUBMITTER: Li Z 

PROVIDER: S-EPMC8771526 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature