Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration.

ABSTRACT: Aims: Neonatal immunity is functionally immature and skewed towards a T_H2-driven, anti-inflammatory profile. This neonatal immunotolerance is partly driven by the type 2 cytokines: interleukin-4 (IL-4) and interleukin-13 (IL-13). Studies on neonatal cardiac regeneration reveal the beneficial role of an anti-inflammatory response in restoring cardiac function after injury. However, the role of an imbalanced immune repertoire observed in neonates on tissue regeneration is poorly understood; specifically, whether IL-4 and IL-13 actively modulate neonatal immunity during cardiac injury. Methods and results: Neonatal mice lacking IL-4 and IL-13 (DKOs) examined at 2 days after birth exhibited reduced anti-inflammatory immune populations with basal cardiac immune populati

SUBMITTER: Chen FM 

PROVIDER: S-EPMC8771554 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature