Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk.

ABSTRACT:

Background

Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program.

Methods

Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and χ²-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed.

Results

Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD))

SUBMITTER: Bohm M 

PROVIDER: S-EPMC8772075 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature