Association between oral antimalarial medication administration and mortality among patients with Ebola virus disease: a multisite cohort study.

ABSTRACT:

Background

Empiric antimalarial treatment is a component of protocol-based management of Ebola virus disease (EVD), yet this approach has limited clinical evidence for patient-centered benefits.

Methods

This retrospective cohort study evaluated the association between antimalarial treatment and mortality among patients with confirmed EVD. The data was collected from five International Medical Corps operated Ebola Treatment Units (ETUs) in Sierra Leone and Liberia from 2014 through 2015. The standardized protocol used for patient care included empiric oral treatment with combination artemether and lumefantrine, twice daily for three days; however, only a subset of patients received treatment due to resource variability. The outcome of interest was mortality, comparing patient

SUBMITTER: Abel L 

PROVIDER: S-EPMC8772178 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature