Mechanisms of flecainide induced negative inotropy: An in silico study.

ABSTRACT: It is imperative to develop better approaches to predict how antiarrhythmic drugs with multiple interactions and targets may alter the overall electrical and/or mechanical function of the heart. Safety Pharmacology studies have provided new insights into the multi-target effects of many different classes of drugs and have been aided by the addition of robust new in vitro and in silico technology. The primary focus of Safety Pharmacology studies has been to determine the risk profile of drugs and drug candidates by assessing their effects on repolarization of the cardiac action potential. However, for decades experimental and clinical studies have described substantial and potentially detrimental effects of Na⁺ channel blockers in addition to their well-known conduction slowing e

SUBMITTER: Yang PC 

PROVIDER: S-EPMC8772296 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature