Genetic Variants and Their Associations to Type 2 Diabetes Mellitus Complications in the United Arab Emirates.

ABSTRACT:

Aim

Type 2 Diabetes Mellitus (T2DM) is associated with microvascular complications, including diabetic retinopathy (DR), diabetic nephropathy (DNp), and diabetic peripheral neuropathy (DPN). In this study, we investigated genetic variations and Single Nucleotide Polymorphisms (SNPs) associated with DR, DNp, DPN and their combinations among T2DM patients of Arab origin from the United Arab Emirates, to establish the role of genes in the progression of microvascular diabetes complications.

Methods

A total of 158 Emirati patients with T2DM were recruited in this study. The study population was divided into 8 groups based on the presence of single, dual, or all three complications. SNPs were selected for association analyses through a search of publicly available databases, spec

SUBMITTER: ElHajj Chehadeh S 

PROVIDER: S-EPMC8772337 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature