In Silico Research of New Therapeutics Rotenoids Derivatives against Leishmania amazonensis Infection.

ABSTRACT: Yearly, 1,500,000 cases of leishmaniasis are diagnosed, causing thousands of deaths. To advance in its therapy, we present an interdisciplinary protocol that unifies ethnobotanical knowledge of natural compounds and the latest bioinformatics advances to respond to an orphan disease such as leishmaniasis and specifically the one caused by Leishmania amazonensis. The use of ethnobotanical information serves as a basis for the development of new drugs, a field in which computer-aided drug design (CADD) has been a revolution. Taking this information from Amazonian communities, located in the area with a high prevalence of this disease, a protocol has been designed to verify new leads. Moreover, a method has been developed that allows the evaluation of lead molecules, and the improvement

SUBMITTER: Vicente-Barrueco A 

PROVIDER: S-EPMC8772715 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature