Combination Biomarker of Immune Checkpoints Predict Prognosis of Urothelial Carcinoma.

ABSTRACT: In contrast to Western counties, the incidence of urothelial carcinoma (UC) remains mar-edly elevated in Taiwan. Regulatory T cells (Tregs) play a crucial role in limiting immune responses within the tumor microenvironment. To elucidate the relationship between immune checkpoints in the tumor immune microenvironment and UC progression, we utilize the Gene Expression Omnibus (GEO) to analyze a microarray obtained from 308 patients with UC. We observed that the expression level of CD276 or TIM-3 was positively correlated with late-stage UC and poor prognosis. Patients with simultaneously high CD276 and TIM-3 expression in tumors have significantly reduced both univariate and multivariate survival, indicating that mRNA levels of these immune checkpoints could be in

SUBMITTER: Tsai CY 

PROVIDER: S-EPMC8772792 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature