Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids.

ABSTRACT: Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible mechanism of platelet aggregation suppression by newly synthesized myrtenol-derived monoterpenoids carrying different heteroatoms (sulphur, oxygen, or nitrogen). Despite all tested compounds suppressed the platelet aggregation in vitro, the most significant effect was observed for the S-containing compounds. The molecular docking confirmed the putative interaction of all tested compounds with the platelet's P2Y12 receptor suggesting that the anti-aggregation properties of monoterpenoids are implemented by blocking the P2Y12 function. The calculated binding force depended on heteroatom in monoterpenoids and significantly decreased with t

SUBMITTER: Nikitina LE 

PROVIDER: S-EPMC8773274 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature