Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma.

ABSTRACT: Diabetes mellitus renders patients susceptible to chronic wounds and various infections. Regarding the latter, fungal infections are of particular concern since, although they are the source of significant morbidity and mortality in immunocompromised patients, they are generally resistant to conventional treatment and a definite treatment strategy has not yet been established. Herein, we report the treatment of skin wounds in a diabetic rat model, infected by Candida albicans, with low temperature helium plasma generated in a hand-held atmospheric jet device. A fungal infection was induced on two dorsal skin wounds of the diabetic rats, and one wound was treated with the plasma jet whereas the other served as a control. Histological analysis revealed accelerated skin wound healing a

SUBMITTER: Choi KY 

PROVIDER: S-EPMC8773309 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature