Muscular and Tendon Degeneration after Achilles Rupture: New Insights into Future Repair Strategies.

ABSTRACT: Achilles tendon rupture is a frequent injury with an increasing incidence. After clinical surgical repair, aimed at suturing the tendon stumps back into their original position, the repaired Achilles tendon is often plastically deformed and mechanically less strong than the pre-injured tissue, with muscle fatty degeneration contributing to function loss. Despite clinical outcomes, pre-clinical research has mainly focused on tendon structural repair, with a lack of knowledge regarding injury progression from tendon to muscle and its consequences on muscle degenerative/regenerative processes and function. Here, we characterize the morphological changes in the tendon, the myotendinous junction and muscle belly in a mouse model of Achilles tendon complete rupture, finding cellular and fatty in

SUBMITTER: Gil-Melgosa L 

PROVIDER: S-EPMC8773411 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature