Nuclear Localization of BRAF^V600E Is Associated with HMOX-1 Upregulation and Aggressive Behavior of Melanoma Cells.

ABSTRACT:

Background

Previously, we have demonstrated that nuclear BRAF^V600E is associated with melanoma aggressiveness and vemurafenib resistance. However, the underlying mechanisms of how nuclear localization of BRAF^V600E promotes cell aggressiveness have not yet been investigated. Despite therapeutic advancements targeting cutaneous melanoma, unknown cellular processes prevent effective treatment for this malignancy, prompting an urgent need to identify new biological targets. This study aims to explore the association of inducible heme oxygenase 1 (HMOX-1) with nuclear BRAF^V600E in promoting melanoma aggressiveness.

Methods

Proteomics analysis was performed to identify the interacting partner(s) of nuclear BRAF^V600E. Immunohistochemistry

SUBMITTER: Zerfaoui M 

PROVIDER: S-EPMC8773521 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature