Dynamic Intercell Communication between Glioblastoma and Microenvironment through Extracellular Vesicles.

ABSTRACT: Glioblastoma is simultaneously the most common and most aggressive primary brain tumor in the central nervous system, with poor patient survival and scarce treatment options. Most primary glioblastomas reoccur and evolve radio- and chemoresistant properties which make them resistant to further treatments. Based on gene mutations and expression profiles, glioblastoma is relatively well classified; however, research shows that there is more to glioblastoma biology than that defined solely by its genetic component. Specifically, the overall malignancy of the tumor is also influenced by the dynamic communication to its immediate and distant environment, as important messengers to neighboring cells in the tumor microenvironment extracellular vesicles (EVs) have been identified. EVs and their ca

SUBMITTER: Krapez G 

PROVIDER: S-EPMC8773537 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature