Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review.

ABSTRACT: Leukemia is the most common type of cancer among children and adolescents worldwide. The aim of this umbrella review was (1) to provide a synthesis of the environmental risk factors for the onset of childhood acute lymphoblastic leukemia (ALL) by exposure window, (2) evaluate their strength of evidence and magnitude of risk, and as an example (3) estimate the prevalence in the German population, which determines the relevance at the population level. Relevant systematic reviews and pooled analyses were identified and retrieved through PubMed, Web of Science databases and lists of references. Only two risk factors (low doses of ionizing radiation in early childhood and general pesticide exposure during maternal preconception/pregnancy) were convincingly associated with childhood ALL. Other

SUBMITTER: Onyije FM 

PROVIDER: S-EPMC8773598 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature