Radiomics-Based Detection of Radionecrosis Using Harmonized Multiparametric MRI.

ABSTRACT: In this study, a radiomics analysis was conducted to provide insights into the differentiation of radionecrosis and tumor progression in multiparametric MRI in the context of a multicentric clinical trial. First, the sensitivity of radiomic features to the unwanted variability caused by different protocol settings was assessed for each modality. Then, the ability of image normalization and ComBat-based harmonization to reduce the scanner-related variability was evaluated. Finally, the performances of several radiomic models dedicated to the classification of MRI examinations were measured. Our results showed that using radiomic models trained on harmonized data achieved better predictive performance for the investigated clinical outcome (balanced accuracy of 0.61 with the model based on ra

SUBMITTER: Acquitter C 

PROVIDER: S-EPMC8773614 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature