Treatment of Intrahepatic Cholangiocarcinoma-A Multidisciplinary Approach.

ABSTRACT: Intrahepatic cholangiocarcinoma (iCC) is distinguished as an entity from perihilar and distal cholangiocarcinoma and gallbladder carcinoma. Recently, molecular profiling and histopathological features have allowed further classification. Due to the frequent delay in diagnosis, the prognosis for iCC remains poor despite major technical advances and multimodal therapeutic approaches. Liver resection represents the therapeutic backbone and only curative treatment option, with the functional residual capacity of the liver and oncologic radicality being deciding factors for postoperative and long-term oncological outcome. Furthermore, in selected cases and depending on national guidelines, liver transplantation may be a therapeutic option. Given the often advanced tumor stage at diagnosis or th

SUBMITTER: Krenzien F 

PROVIDER: S-EPMC8773654 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature