Mutation of the Conserved Threonine 8 within the Human ARF Tumour Suppressor Protein Regulates Autophagy.

ABSTRACT:

Background

The ARF tumour suppressor plays a well-established role as a tumour suppressor, halting cell growth by both p53-dependent and independent pathways in several cellular stress response circuits. However, data collected in recent years challenged the traditional role of this protein as a tumour suppressor. Cancer cells expressing high ARF levels showed that its expression, far from being dispensable, is required to guarantee tumour cell survival. In particular, ARF can promote autophagy, a self-digestion pathway that helps cells cope with stressful growth conditions arising during both physiological and pathological processes.

Methods

We previously showed that ARF is regulated through the activation of the protein kinase C (PKC)-dependent pathway and that an ARF phos

SUBMITTER: Fontana R 

PROVIDER: S-EPMC8773949 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature