Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications.

ABSTRACT: Ribosome biogenesis is a cellular process critical for protein homeostasis during cell growth and multiplication. Our previous study confirmed up-regulation of ribosome biogenesis during endometriosis progression and malignant transition, thus anti-ribosome biogenesis may be effective for treating endometriosis and the associated complications. A mouse model with human endometriosis features was established and treated with three different drugs that can block ribosome biogenesis, including inhibitors against mTOR/PI3K (GSK2126458) and RNA polymerase I (CX5461 and BMH21). The average lesion numbers and disease frequencies were significantly reduced in treated mice as compared to controls treated with vehicle. Flow cytometry analyses confirmed the reduction of small peritoneal macrophage an

SUBMITTER: Chang CY 

PROVIDER: S-EPMC8774031 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature