Sexual Dimorphism in Metabolic Responses to Western Diet in Drosophila melanogaster.

ABSTRACT: Obesity is a chronic disease affecting millions of people worldwide. The fruit fly (Drosophila melanogaster) is an interesting research model to study metabolic and transcriptomic responses to obesogenic diets. However, the sex-specific differences in these responses are still understudied and perhaps underestimated. In this study, we exposed adult male and female Dahomey fruit flies to a standard diet supplemented with sugar, fat, or a combination of both. The exposure to a diet supplemented with 10% sugar and 10% fat efficiently induced an increase in the lipid content in flies, a hallmark for obesity. This increase in lipid content was more prominent in males, while females displayed significant changes in glycogen content. A strong effect of the diets on the ovarian size and number of

SUBMITTER: De Groef S 

PROVIDER: S-EPMC8774106 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature