How Far Are We from the Completion of the Human Protein Interactome Reconstruction?

ABSTRACT: After more than fifteen years from the first high-throughput experiments for human protein-protein interaction (PPI) detection, we are still wondering how close the completion of the genome-scale human PPI network reconstruction is, what needs to be further explored and whether the biological insights gained from the holistic investigation of the current network are valid and useful. The unique structure of PICKLE, a meta-database of the human experimentally determined direct PPI network developed by our group, presently covering ~80% of the UniProtKB/Swiss-Prot reviewed human complete proteome, enables the evaluation of the interactome expansion by comparing the successive PICKLE releases since 2013. We observe a gradual overall increase of 39%, 182%, and 67% in protein nodes, PPIs, and s

SUBMITTER: Dimitrakopoulos GN 

PROVIDER: S-EPMC8774112 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature