The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes.

ABSTRACT: Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other diseases. Specifically, recent efforts have focused on serine protease inhibitors, known as serpins, as potential therapeutic targets. The serpin protein family comprises a broad range of protease inhibitors, which are categorized into 16 clades that are all extracellular, with the exception of Clade B, which controls mostly intracellular proteases, including both serine- and papain-like cysteine proteases. This review discusses the most salient, and sometimes opposing, views that either inhibitio

SUBMITTER: Kryvalap Y 

PROVIDER: S-EPMC8774208 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature