Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.

ABSTRACT:

Background

Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity.

Methods

For up to N = 389 genotyped participants of the PROGRESS study of hospitalised CAP patients, we performed a genome-wide association study of ten cytokines IL-1β, IL-6, IL-8, IL-10, IL-12, MCP-1 (MCAF), MIP-1α (CCL3), VEGF, VCAM-1, and ICAM-1. Consecutive secondary analyses were performed to identify independent hits and corresponding causal variants.

Results

102 SNPs from 14 loci showed genome-wide significant associations with five of the cytokines. The most interesting associations were found at 6p21.1 for VEGF (

SUBMITTER: Kuhnapfel A 

PROVIDER: S-EPMC8774373 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature