Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers.

ABSTRACT: Pediatric brain tumors represent the most common types of childhood cancer and novel diagnostic and therapeutic solutions are urgently needed. The gold standard treatment option for brain cancers in children, as in adults, is tumor resection followed by radio- and chemotherapy, but with discouraging therapeutic results. In particular, the last two treatments are often associated to significant neurotoxicity in the developing brain of a child, with resulting disabilities such as cognitive problems, neuroendocrine, and neurosensory dysfunctions/deficits. Nanoparticles have been increasingly and thoroughly investigated as they show great promises as diagnostic tools and vectors for gene/drug therapy for pediatric brain cancer due to their ability to cross the blood-brain barrier. In this revi

SUBMITTER: Guido C 

PROVIDER: S-EPMC8774904 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature