Emerging Links between Microbiome Composition and Skin Immunology in Diaper Dermatitis: A Narrative Review.

ABSTRACT: Diaper dermatitis is a common type of irritant contact dermatitis occurring in infants and toddlers. Its occurrence is triggered by an unfavorable environment under the diaper, damage to skin integrity by fecal enzyme degradation, overhydration and disruption of the lipid bilayer structure facilitating the entry of irritants and microorganisms. In diaper dermatitis development, the central proinflammatory cytokines are IL-1α, IL-8 and TNF-α. The initial release of IL-1α and TNF-α starts a further cascade of pro-inflammatory chemo- and cytokines, resulting in inflammation and erythema of the skin. A recently recognized factor in diaper dermatitis is the composition of the skin microbiome; common pathogenic strains Candida albicans and Staphylococcus aureus are associated with

SUBMITTER: Hertis Petek T 

PROVIDER: S-EPMC8775025 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature