Circulatory MicroRNAs in Plasma and Atrial Fibrillation in the General Population: The Rotterdam Study.

ABSTRACT: MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have been shown to play an important role in cardiovascular disease. However, limited population-based data regarding the relationship between circulatory miRNAs in plasma and atrial fibrillation (AF) exist. Moreover, it remains unclear if the relationship differs by sex. We therefore aimed to determine the (sex-specific) association between plasma circulatory miRNAs and AF at the population level. Plasma levels of miRNAs were measured using a targeted next-generation sequencing method in 1999 participants from the population-based Rotterdam Study. Logistic regression and Cox proportional hazards models were used to assess the associations of 591 well-expressed miRNAs with the prevalence and incidence of AF. Models were

SUBMITTER: Geurts S 

PROVIDER: S-EPMC8775308 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature