Deep Conservation of Histone Variants in Thermococcales Archaea.

ABSTRACT: Histones are ubiquitous in eukaryotes where they assemble into nucleosomes, binding and wrapping DNA to form chromatin. One process to modify chromatin and regulate DNA accessibility is the replacement of histones in the nucleosome with paralogous variants. Histones are also present in archaea but whether and how histone variants contribute to the generation of different physiologically relevant chromatin states in these organisms remains largely unknown. Conservation of paralogs with distinct properties can provide prima facie evidence for defined functional roles. We recently revealed deep conservation of histone paralogs with different properties in the Methanobacteriales, but little is known experimentally about these histones. In contrast, the two histones of the model archaeon Thermo

SUBMITTER: Stevens KM 

PROVIDER: S-EPMC8775648 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature