Sex Differences in Long-term Outcomes After Group B Streptococcal Infections During Infancy in Denmark and the Netherlands: National Cohort Studies of Neurodevelopmental Impairments and Mortality.

ABSTRACT:

Background

Male infants have a higher incidence of invasive group B Streptococcus disease (iGBS) compared with female infants; however, data on sex differences in mortality and long-term outcomes after iGBS are lacking. We assessed whether a child's sex influences the effects of iGBS on mortality and risk of neurodevelopmental impairments (NDIs).

Methods

We used Danish and Dutch registry data to conduct a nationwide cohort study of infants with a history of iGBS. A comparison cohort, children without a history of iGBS, was randomly selected and matched on relevant factors. Effect modification by sex was assessed on additive and multiplicative scales.

Results

Our analyses included data from children with a history of iGBS in Denmark (period 1997 -2017; n = 1432) and th

SUBMITTER: van Kassel MN 

PROVIDER: S-EPMC8775649 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature