Circadian Gene Selection for Time-to-event Phenotype by Integrating CNV and RNAseq Data.

ABSTRACT: The endogenous circadian clock, which controls daily rhythms in the expression of at least half of the mammalian genome, has a major influence on cell physiology. Consequently, disruption of the circadian system is associated with wide range of diseases including cancer. While several circadian clock genes have been associated with cancer progression, little is known about the survival when two or more platforms are considered together. Our goal was to determine if survival outcomes are associated with circadian clock function. To accomplish this goal, we developed a Bayesian hierarchical survival model coupled with the global local shrinkage prior and applied this model to available RNASeq and Copy Number Variation data to select significant circadian genes associates with cancer progress

SUBMITTER: Maity AK 

PROVIDER: S-EPMC8775911 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature