Association between pre-diagnostic circulating adipokines and colorectal cancer and adenoma in the CLUE II cohort.

ABSTRACT:

Objective

Obesity is a known risk factor for colorectal cancer (CRC) and adenoma. Obese individuals have higher circulating concentrations of certain endocrine and immune factors produced by adipocytes thought to partially underlie the association between obesity and colorectal neoplasia. Thus, we evaluated the association of plasma concentrations of adiponectin, leptin, and soluble tumor necrosis factor receptor-2 (sTNFR2) with CRC and adenoma.

Methods

We ascertained 193 CRC cases and 193 matched controls, and 131 colorectal adenoma cases and 131 matched controls who had had an endoscopy nested in the CLUE II cohort of Washington County, MD. Plasma markers were measured using ELISA. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from conditional logistic

SUBMITTER: Marrone MT 

PROVIDER: S-EPMC8775936 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature