The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions.

ABSTRACT: Drug addiction causes constant serious health, social, and economic burden within the human society. The current drug dependence pharmacotherapies, particularly relapse prevention, remain limited, unsatisfactory, unreliable for opioids and tobacco, and even symptomatic for stimulants and cannabinoids, thus, new more effective treatment strategies are researched. The antagonism of the growth hormone secretagogue receptor type A (GHS-R1A) has been recently proposed as a novel alcohol addiction treatment strategy, and it has been intensively studied in experimental models of other addictive drugs, such as nicotine, stimulants, opioids and cannabinoids. The role of ghrelin signaling in these drugs effects has also been investigated. The present review aims to provide a comprehensive overview o

SUBMITTER: Sustkova-Fiserova M 

PROVIDER: S-EPMC8776007 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature