Transcriptional Response in a Sepsis Mouse Model Reflects Transcriptional Response in Sepsis Patients.

ABSTRACT: Mortality due to sepsis remains unacceptably high, especially for septic shock patients. Murine models have been used to better understand pathophysiology mechanisms. However, the mouse model is still under debate. Herein we investigated the transcriptional response of mice injected with lipopolysaccharide (LPS) and compared it to either human cells stimulated in vitro with LPS or to the blood cells of septic patients. We identified a molecular signature composed of 2331 genes with an FDR median of 0%. This molecular signature is highly enriched in regulated genes in peritoneal macrophages stimulated with LPS. There is significant enrichment in several inflammatory signaling pathways, and in disease terms, such as pneumonia, sepsis, systemic inflammatory response syndrome, severe sepsis, a

SUBMITTER: Rosier F 

PROVIDER: S-EPMC8776114 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature