ACE2 pathway regulates thermogenesis and energy metabolism.

ABSTRACT: Identification of key regulators of energy homeostasis holds important therapeutic promise for metabolic disorders, such as obesity and diabetes. ACE2 cleaves angiotensin II (Ang II) to generate Ang-(1-7) which acts mainly through the Mas1 receptor. Here, we identify ACE2 pathway as a critical regulator in the maintenance of thermogenesis and energy expenditure. We found that ACE2 is highly expressed in brown adipose tissue (BAT) and that cold stimulation increases ACE2 and Ang-(1-7) levels in BAT and serum. Ace2 knockout mice (Ace2^-/y) and Mas1 knockout mice (Mas1^-/-) displayed impaired thermogenesis. Mice transplanted with brown adipose tissue from Mas1^-/- display metabolic abnormalities consistent with those seen in the

SUBMITTER: Cao X 

PROVIDER: S-EPMC8776250 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature