Global organization of neuronal activity only requires unstructured local connectivity.

ABSTRACT: Modern electrophysiological recordings simultaneously capture single-unit spiking activities of hundreds of neurons spread across large cortical distances. Yet, this parallel activity is often confined to relatively low-dimensional manifolds. This implies strong coordination also among neurons that are most likely not even connected. Here, we combine in vivo recordings with network models and theory to characterize the nature of mesoscopic coordination patterns in macaque motor cortex and to expose their origin: We find that heterogeneity in local connectivity supports network states with complex long-range cooperation between neurons that arises from multi-synaptic, short-range connections. Our theory explains the experimentally observed spatial organization of covariances in resting stat

SUBMITTER: Dahmen D 

PROVIDER: S-EPMC8776256 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature