Decoupling of functional and structural language networks in temporal lobe epilepsy.

ABSTRACT:

Objective

To identify functional and structural alterations in language networks of people with temporal lobe epilepsy (TLE), who frequently present with naming and word-finding difficulties.

Methods

Fifty-five patients with unilateral TLE (29 left) and 16 controls were studied with auditory and picture naming functional magnetic resonance imaging (fMRI) tasks. Activation maxima in the left posterobasal temporal lobe were used as seed regions for whole-brain functional connectivity analyses (psychophysiological interaction). White matter language pathways were investigated using diffusion tensor imaging and neurite orientation dispersion and density imaging metrics extracted along fiber bundles starting from fMRI-guided seeds. Regression analyses were performed to investigat

SUBMITTER: Trimmel K 

PROVIDER: S-EPMC8776336 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature