Primary hypothyroidism in childhood cancer survivors: Prevalence, risk factors, and long-term consequences.

ABSTRACT:

Background

Data on primary hypothyroidism and its long-term impact on the health, cognition, and quality of life (QOL) of childhood cancer survivors are limited. This study examined the prevalence of and risk factors for primary hypothyroidism and its associations with physical, neurocognitive, and psychosocial outcomes.

Methods

This was a retrospective study with a cross-sectional health outcome analysis of an established cohort comprising 2965 survivors of childhood cancer (52.8% male; median current age, 30.9 years, median time since cancer diagnosis, 22.3 years). Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between primary hypothyroidism and cancer-related risk factors, cardiovascular disease risk facto

SUBMITTER: Chemaitilly W 

PROVIDER: S-EPMC8776571 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature