Genome-driven elucidation of phage-host interplay and impact of phage resistance evolution on bacterial fitness.

ABSTRACT: When considering the interactions between bacteriophages and their host, the issue of phage-resistance emergence is a key element in understanding the ecological impact of phages on the bacterial population. It is also an essential parameter for the implementation of phage therapy to combat antibiotic-resistant pathogens. This study investigates the phenotypic and genetic responses of five Pseudomonas aeruginosa strains (PAO1, A5803, AA43, CHA, and PAK) to the infection by seven phages with distinct evolutionary backgrounds and recognised receptors (LPS/T4P). Emerging phage-insensitivity was generally accompanied by self and cross-resistance mechanisms. Significant differences were observed between the reference PAO1 responses compared to other clinical representatives. LPS-dependent phage

SUBMITTER: Markwitz P 

PROVIDER: S-EPMC8776877 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature