Dataset Information

5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.

ABSTRACT: Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT^DRN) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HT^DRN to hypothalamic arcuate nucleus (5-HT^DRN → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT_2C and 5-HT_1B receptors, whereas activation of 5-HT^DRN to ventral tegmental area (5-HT^DRN → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT_2C receptors. Further, hunger-driven feeding gradually activates ARH-projecting 5-HT^DRN neurons via inhibiting their responsiveness to inhibitory GABAergic inputs; non-hunger-driven feeding activates VTA-projecting 5-HT^DRN neurons through reducing a potassium outward current. Thus, our results support a model whereby parallel circuits modulate feeding behavior either in response to hunger or to hunger-independent cues.

SUBMITTER: He Y

PROVIDER: S-EPMC8776930 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.

He Yanlin Y Cai Xing X Liu Hailan H Conde Krisitine M KM Xu Pingwen P Li Yongxiang Y Wang Chunmei C Yu Meng M He Yang Y Liu Hesong H Liang Chen C Yang Tingting T Yang Yongjie Y Yu Kaifan K Wang Julia J Zheng Rong R Liu Feng F Sun Zheng Z Heisler Lora L Wu Qi Q Tong Qingchun Q Zhu Canjun C Shu Gang G Xu Yong Y

Molecular psychiatry 20210721 12

Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HTDRN) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HTDRN to hypothalamic arcuate nucleus (5-HTDRN → ARH) projections inhibits food intake driven by hunger via actions ...[more]

PMID: 34290371

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5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.

Publications

5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.

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