Effect of intrabronchial administration of autologous adipose-derived mesenchymal stem cells on severe equine asthma.

ABSTRACT:

Background

Severe equine asthma (SEA) is a common chronic respiratory disease and a significant health and well-being problem in horses. Current therapeutic strategies improve pulmonary function and clinical signs in some horses, but in the long-term, return to full athletic function appears to be rare. The aim of this study was to assess the safety and the effect of intrabronchial administration of adipose-derived mesenchymal stem cells (AD-MSC) on pulmonary inflammatory and clinical parameters in horses with SEA.

Methods

This was a randomized controlled trial. Twenty adult horses diagnosed with SEA were randomly divided into two groups (n = 10), and treated either with a single intrabronchial application of autologous AD-MSC or oral dexamethasone for three weeks. A targete

SUBMITTER: Adamic N 

PROVIDER: S-EPMC8777441 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature