Mobile Genetic Elements Drive Antimicrobial Resistance Gene Spread in Pasteurellaceae Species.

ABSTRACT: Mobile genetic elements (MGEs) and antimicrobial resistance (AMR) drive important ecological relationships in microbial communities and pathogen-host interaction. In this study, we investigated the resistome-associated mobilome in 345 publicly available Pasteurellaceae genomes, a large family of Gram-negative bacteria including major human and animal pathogens. We generated a comprehensive dataset of the mobilome integrated into genomes, including 10,820 insertion sequences, 2,939 prophages, and 43 integrative and conjugative elements. Also, we assessed plasmid sequences of Pasteurellaceae. Our findings greatly expand the diversity of MGEs for the family, including a description of novel elements. We discovered that MGEs are comparable and dispersed across species and that th

SUBMITTER: da Silva GC 

PROVIDER: S-EPMC8777487 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature