Caffeic acid phenethyl ester (CAPE) confers wild type p53 function in p53^Y220C mutant: bioinformatics and experimental evidence.

ABSTRACT: Mutations in the tumor suppressor protein p53 is a prevalent feature in majority of cancers resulting in inactivation of its activities related to control of cell cycle progression and proliferation. p53^Y220C is one of the common hotspot mutations that causes decrease in its thermodynamic stability. Some small molecules have been shown to bind to the mutated site and restore its wild type thermodynamics and tumor suppressor function. In this study, we have explored the potential of caffeic acid phenethyl ester (CAPE-a bioactive compound from propolis) to interact with p53^Y220C and restore its wild type p53 (p53^wt) transcription activation and tumor suppressor activities. We recruited computational methods, viz. molecular docking, molecular dynamics simulati

SUBMITTER: Radhakrishnan N 

PROVIDER: S-EPMC8777538 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature