In-Person vs Electronic Directly Observed Therapy for Tuberculosis Treatment Adherence: A Randomized Noninferiority Trial.

ABSTRACT:

Importance

Electronic directly observed therapy (DOT) is used increasingly as an alternative to in-person DOT for monitoring tuberculosis treatment. Evidence supporting its efficacy is limited.

Objective

To determine whether electronic DOT can attain a level of treatment observation as favorable as in-person DOT.

Design, setting, and participants

This was a 2-period crossover, noninferiority trial with initial randomization to electronic or in-person DOT at the time outpatient tuberculosis treatment began. The trial enrolled 216 participants with physician-suspected or bacteriologically confirmed tuberculosis from July 2017 to October 2019 in 4 clinics operated by the New York City Health Department. Data analysis was conducted between March 2020 and April 2021.

In

SUBMITTER: Burzynski J 

PROVIDER: S-EPMC8777548 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature