Upregulation of TCF21 inhibits migration of adrenocortical carcinoma cells.

ABSTRACT:

Background

Adrenocortical carcinomas (ACC) are rare and aggressive cancer. Our previous study has revealed that the transcription factor 21, TCF21, is downregulated in ACC and regulates steroidogenic factor 1 (SF-1) binding to the SF-1 E-box promoter. In addition, it could be found that TCF21 is a predictor of overall survival (OS) in adult carcinomas.

Methods

In this study, it was investigated the correlation between TCF21 expression and the promoter methylation status in adrenocortical tumor cells, carcinomas and adenoma. The biological function and potential molecular mechanism of TCF21 restoration in migration and invasion of ACC cells was examined.

Results

We could be demonstrated a negative correlation between the level of TCF21 expression and methylation of its

SUBMITTER: Kremer JL 

PROVIDER: S-EPMC8777580 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature