Thermodynamic Modeling of Solvent-Assisted Lipid Bilayer Formation Process.

ABSTRACT: The solvent-assisted lipid bilayer (SALB) formation method provides a simple and efficient, microfluidic-based strategy to fabricate supported lipid bilayers (SLBs) with rich compositional diversity on a wide range of solid supports. While various studies have been performed to characterize SLBs formed using the SALB method, relatively limited work has been carried out to understand the underlying mechanisms of SALB formation under various experimental conditions. Through thermodynamic modeling, we studied the experimental parameters that affect the SALB formation process, including substrate surface properties, initial lipid concentration, and temperature. It was found that all the parameters are critically important to successfully form high-quality SLBs. The model also helps to identify

SUBMITTER: Xu H 

PROVIDER: S-EPMC8777629 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature